ANTI TPO - Thyro Peroxidase Antibodies (TPO)

Key Aspects of the Anti-TPO Test:

• Purpose: The test determines if a thyroid condition is caused by an autoimmune attack, where the body's immune system attacks the thyroid peroxidase enzyme necessary for producing thyroid hormones.
• Significance of Results:
  • High Levels: Strongly suggest Autoimmune Thyroiditis (Hashimoto's) or less frequently, Graves' disease.
  • Low/Negative Levels: Suggests the absence of these specific antibodies.
• When It's Needed: Doctors prescribe this test if patients have symptoms of high or low thyroid function (e.g., palpitations, weight changes, goiter) or to check risk during pregnancy.

Common Conditions Associated with High TPO Antibodies:

• Hashimoto’s Thyroiditis: The most common cause of high levels, usually causing hypothyroidism.
• Graves’ Disease: Can cause high levels, usually causing hyperthyroidism.
• Postpartum Thyroiditis: Risk increases in pregnancy.

High TPO antibodies can be found in some individuals without active disease, but it may signify a high risk for developing one in the future.