Bile Acid, Total

Key Aspects of Total Bile Acid Testing

• Purpose: Measures liver function and detects liver injury or impaired bile flow.
• Normal Range: Generally 0.5 – 10 $\mu$mol/L; levels >10 $\mu$mol/L suggest impaired bile flow (cholestasis) or liver disease.
• Pregnancy (ICP): Levels >10–40 $\mu$mol/L indicate ICP, a condition posing risks to the fetus. Severe cases are often defined as >40 $\mu$mol/L.
• Symptoms of High Levels: Jaundice, intense itching (especially in pregnancy), dark urine, and abdominal pain.
• Preparation: An overnight fast (8–12 hours) is usually required.

Clinical Relevance

• Liver Function Evaluation: Elevated TBA levels indicate decreased hepatic extraction or cholestasis.
• Cholestasis of Pregnancy: Used to monitor women with pruritus (itching) during late pregnancy.
• Follow-up: High results warrant further investigation into liver diseases such as cirrhosis or hepatitis.

*Disclaimer: Test result ranges can vary by laboratory, and results should always be interpreted by a healthcare professional.*